caa a22 4500 469119063 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245487 doi (NATIONALLICENCE)springer-10.1007/BF02245487 Differential development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol [Elektronische Daten] [A. Lê, M. Mana, B. Quan, H. Kalant] The development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol was examined. Acute tolerance to the motor impairment effect of ethanol was shown by a decrease in the degree of intoxication, as measured on the moving belt task, at higher blood ethanol levels ranging from 206 to 256 mg/dl. There was no evidence of acute tolerance to the anticonvulsant effect of ethanol in rats tested over the same time period. These results indicate that, like chronic tolerance, acute tolerance to ethanol develops at different rates for different effects of the drug. The fact that chronic tolerance to the anticonvulsant effect of ethanol has been well documented raises doubts about the assumption that similar physiological changes underlie acute and chronic tolerance to a drug effect, and support the idea that the relationship between acute and chronic tolerance is more complex than previously thought. Springer-Verlag, 1992 Acute tolerance nationallicence Motor impairment nationallicence Anticonvulsant nationallicence Ethanol nationallicence Lê A. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Mana M. Department of Behavioral Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA aut Quan B. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Kalant H. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 107-111 0033-3158 109:1-2<107 1992 109 213 https://doi.org/10.1007/BF02245487 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245487 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lê A. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Mana M. Department of Behavioral Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Quan B. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kalant H. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 107-111 0033-3158 109:1-2<107 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer