caa a22 4500 469119098 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245488 doi (NATIONALLICENCE)springer-10.1007/BF02245488 Tolerance to ethanol's effects on operant performance in rats: role of number and pattern of intoxicated practice opportunities [Elektronische Daten] [Frank Holloway, Ron Michaelis, Richard Harland, José Criado, David Gauvin] Acquisition and retention of tolerance to ethanol's rate-decreasing effects on operant performance were examined in rats which received a 52-day regimen of ethanol or saline injections prior to and/or after each daily session. Eight groups of rats differed on: (a) number of days with intoxicated practice (pre-session ethanol); (b) intermittent (spaced) or daily (massed) intoxicated practice; and (c) post-session ethanol or saline on nonintoxicated practice days. Massed practice groups were given their presession saline days prior to their pre-session ethanol days. Ethanol dose-effect tests were given prior to, during, and after the chronic injection regimen. Under both spaced and massed practice conditions, the magnitude of tolerance developed increased directly with the number of pre-session ethanol days, even when absolute ethanol exposure was constant. No group showed complete tolerance loss. The post-session ethanol supplements (a) facilitated tolerance development in spaced practice groups and tolerance loss in massed practice groups, (b) blocked ethanol's low dose rate-increasing effects, and (c) produced an acute withdrawal-like performance disruption the next day. The results suggest that both intoxicated practice and practice during acute ethanol withdrawal influence the acquisition and retention of compensatory behaviors during ethanol tolerance development. Springer-Verlag, 1992 Ethanol nationallicence Operant performance nationallicence Tolerance nationallicence Intoxicated practice nationallicence Compensatory behaviors nationallicence Acute ethanol withdrawal nationallicence Holloway Frank Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut Michaelis Ron Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut Harland Richard Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut Criado José Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut Gauvin David Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 112-120 0033-3158 109:1-2<112 1992 109 213 https://doi.org/10.1007/BF02245488 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245488 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holloway Frank Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut NATIONALLICENCE 700 1- Michaelis Ron Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut NATIONALLICENCE 700 1- Harland Richard Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut NATIONALLICENCE 700 1- Criado José Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut NATIONALLICENCE 700 1- Gauvin David Psychobiology Laboratories, Department of Psychiatry and Behavioral Sciences, University of Oklahoma, Health Sciences Center, Research Building, 306R, P.O. Box 26901, 73190, Oklahoma City, OK, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 112-120 0033-3158 109:1-2<112 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer