caa a22 4500 469119152 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245500 doi (NATIONALLICENCE)springer-10.1007/BF02245500 Wetherell Anthony Human Factors Section, Chemical and Biological Defence Establishment, Porton Down, SP4 0JQ, Salisbury, UK aut Effects of physostigmine on stimulus encoding in a memory-scanning task [Elektronische Daten] [Anthony Wetherell] Previous studies of the effects of physostigmine on memory have involved other drugs, a memory that has already been impaired, or both, often with contradictory results. Also, traditional memory tests do not differentiate memory from other task components such as perception and response, and drug effects on these could be mistaken for effects on memory. The present study was designed to investigate the effects of physostigmine alone on normal memory using Sternberg's additive-factor, memory-scanning task, with additional variables to isolate effects on stimulus encoding and response stages. Sixteen volunteers participated, the design was between-groups, and physostigmine or normal saline was given, double-blind, by intravenous infusion for 70 min. The drug had no effect on the memory component of the task, but significantly improved stimulus encoding (P<0.001). Thus, it is possible that physostigmine improves performance on memory tests by improving perception as well as, or instead of, memory. Springer-Verlag, 1992 Physostigmine nationallicence Stimulus encoding nationallicence Memory scanning nationallicence Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 198-202 0033-3158 109:1-2<198 1992 109 213 https://doi.org/10.1007/BF02245500 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245500 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wetherell Anthony Human Factors Section, Chemical and Biological Defence Establishment, Porton Down, SP4 0JQ, Salisbury, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 198-202 0033-3158 109:1-2<198 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer