caa a22 4500 469119179 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245507 doi (NATIONALLICENCE)springer-10.1007/BF02245507 Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice [Elektronische Daten] [Minoru Narita, Tsutomu Suzuki, Miwa Misawa, Hiroshi Nagase] Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 µg, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of μ agonists. Springer-Verlag, 1992 Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels nationallicence Morphine nationallicence Hyperthermia nationallicence Narita Minoru Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Suzuki Tsutomu Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Misawa Miwa Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut Nagase Hiroshi Basic Research Laboratories, Toray Industries, 248, Kamakura, Japan aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 239-240 0033-3158 109:1-2<239 1992 109 213 https://doi.org/10.1007/BF02245507 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245507 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Narita Minoru Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Tsutomu Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 700 1- Misawa Miwa Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, 142, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagase Hiroshi Basic Research Laboratories, Toray Industries, 248, Kamakura, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 239-240 0033-3158 109:1-2<239 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer