caa a22 4500 469119187 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245483 doi (NATIONALLICENCE)springer-10.1007/BF02245483 Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat [Elektronische Daten] [T. Wilckens, U. Schweiger, K. Pirke] Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20-30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation. Springer-Verlag, 1992 Serotonin nationallicence 5-HT nationallicence 5-HT receptors nationallicence 5-HT1C receptors nationallicence 5-HT agonists nationallicence mCPP nationallicence Exercise nationallicence Anorexia nationallicence Stress nationallicence Hyperactivity nationallicence Food intake nationallicence Starvation nationallicence Wilckens T. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut Schweiger U. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut Pirke K. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 77-84 0033-3158 109:1-2<77 1992 109 213 https://doi.org/10.1007/BF02245483 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245483 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilckens T. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schweiger U. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut NATIONALLICENCE 700 1- Pirke K. Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 77-84 0033-3158 109:1-2<77 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer