caa a22 4500 469119195 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF02245505 doi (NATIONALLICENCE)springer-10.1007/BF02245505 Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function [Elektronische Daten] [Michael Newman, Bernard Lerer, Pesach Lichtenberg, Baruch Shapira] Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer-Verlag, 1992 Antidepressant nationallicence Lithium nationallicence Adenylate cyclase nationallicence Platelet nationallicence Human nationallicence Newman Michael Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Lerer Bernard Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Lichtenberg Pesach Yaacov Herzog Centre for Brain and Psychiatry Research, Ezrath Nashim-Herzog Hospital, Jerusalem, Israel aut Shapira Baruch Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 231-234 0033-3158 109:1-2<231 1992 109 213 https://doi.org/10.1007/BF02245505 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245505 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Newman Michael Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Lerer Bernard Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Lichtenberg Pesach Yaacov Herzog Centre for Brain and Psychiatry Research, Ezrath Nashim-Herzog Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Shapira Baruch Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 109/1-2(1992-10-01), 231-234 0033-3158 109:1-2<231 1992 109 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer