caa a22 4500 469119217 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245119 doi (NATIONALLICENCE)springer-10.1007/BF02245119 Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients [Elektronische Daten] [Bonnie Spring, Alan Gelenberg, Rob Garvin, Sheri Thompson] No longer prescribed only for vegetative signs of depression, tricyclic antidepressants also lessen depressive cognitive distortions. Less clear is whether they ameliorate depressed patients' other cognitive deficits in memory, information processing speed, and psychomotor performance. We tested the alternative hypothesis that amitriptyline, because of its anticholinergic and sedative properties, would exacerbate depressed patients' cognitive disturbances. Depressed outpatients received double-blind placebo (n=15), amitriptyline (n=10), or clovoxamine fumarate (n=10), a serotonin reuptake inhibitor relatively lacking in anticholinergic properties. Depression, memory, and psychomotor performance were assessed at baseline and after 7 and 28 days of drug treatment. Depression was alleviated after all treatments, including placebo. Only amitriptyline impaired performance on tests of memory, producing a significant decrement, relative to placebo, after 4 weeks of treatment. None of the treatments adversely affected performance on psychomotor tasks. These findings add to the evidence that antidepressant drugs with high anticholinergic activity can impair memory, despite alleviation of depression. Springer-Verlag, 1992 Antidepressants nationallicence Tricyclics nationallicence Memory nationallicence Amitriptyline nationallicence Clovoxamine nationallicence Anticholinergic nationallicence Spring Bonnie Department of Psychology, University of Health Sciences, The Chicago Medical School, 3333 Green Bay Road, 60064, North Chicago, IL, USA aut Gelenberg Alan Department of Psychiatry, University of Arizona, Health Sciences Center, 85724, Tucson, AZ, USA aut Garvin Rob Department of Psychology, Texas Tech University, 79409, Lubbock, TX, USA aut Thompson Sheri Department of Psychology, Texas Tech University, 79409, Lubbock, TX, USA aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 327-332 0033-3158 108:3<327 1992 108 213 https://doi.org/10.1007/BF02245119 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245119 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spring Bonnie Department of Psychology, University of Health Sciences, The Chicago Medical School, 3333 Green Bay Road, 60064, North Chicago, IL, USA aut NATIONALLICENCE 700 1- Gelenberg Alan Department of Psychiatry, University of Arizona, Health Sciences Center, 85724, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Garvin Rob Department of Psychology, Texas Tech University, 79409, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Thompson Sheri Department of Psychology, Texas Tech University, 79409, Lubbock, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 327-332 0033-3158 108:3<327 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer