caa a22 4500 469119225 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245114 doi (NATIONALLICENCE)springer-10.1007/BF02245114 Effects of buspirone and gepirone on IV cocaine self-administration in rhesus monkeys [Elektronische Daten] [Lisa Gold, Robert Balster] Buspirone and gepirone were evaluated as potential pharmacotherapies for cocaine abuse by studying the effects of acute and repeated treatment on IV cocaine self-administration in rhesus monkeys. Chlorpromazine was also evaluated as a positive control. Effects of IV drug pretreatments were tested during daily 60-min sessions with lever-pressing reinforced under a fixed-ratio 10 schedule of 0.02 or 0.05 mg/kg cocaine infusions. Acute pretreatment with buspirone (0.1 and 0.3 mg/kg, IV) increased rates of cocaine self-administration without disrupting food pellet consumption. Some doses of buspirone also produced changes in rates of cocaine self-administration without altering the within-session pattern of responding. In contrast, acute doses of gepirone had little effect on rates of cocaine self-administration, while disruptions in food consumption and changes in the within-session pattern of cocaine self-administration were obtained at the highest dose of gepirone tested (1.0 mg/kg). When either buspirone (0.1 and 0.3 mg/kg, IV) or gepirone (0.1 mg/kg, IV) were administered daily for 10 days, consistent effects on cocaine self-administration were not observed. Thus, the effects of acute buspirone administration on cocaine-maintained behavior were similar to the effects produced by chlorpromazine and other dopaminergic antagonists, whereas, gepirone was ineffective. These results provide some support for further evaluation of buspirone as a potential pharmacotherapy for cocaine abuse, although its lack of efficacy with repeated treatment is not encouraging. The negative results with gepirone provide less rationale for continued investigations with this drug, possibly because of its lesser involvement than buspirone with dopaminergic neurotransmission. Springer-Verlag, 1992 Cocaine abuse nationallicence Buspirone nationallicence Gepirone nationallicence Chlorpromazine nationallicence Self-administration of drugs nationallicence Dopamine antagonists nationallicence Rhesus monkey nationallicence Gold Lisa Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 23298-0613, Richmond, VA, USA aut Balster Robert Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 23298-0613, Richmond, VA, USA aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 289-294 0033-3158 108:3<289 1992 108 213 https://doi.org/10.1007/BF02245114 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gold Lisa Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 23298-0613, Richmond, VA, USA aut NATIONALLICENCE 700 1- Balster Robert Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 23298-0613, Richmond, VA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 289-294 0033-3158 108:3<289 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer