caa a22 4500 469119233 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245108 doi (NATIONALLICENCE)springer-10.1007/BF02245108 Lader Malcolm Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK aut Rebound insomnia and newer hypnotics [Elektronische Daten] [Malcolm Lader] The prescription of hypnotics, mostly benzodiazepines, continues at a high level. One problem with their use is rebound insomnia: upon discontinuation sleep worsens compared with pretreatment levels. Factors influencing rebound include the type of subject, the duration of action of the hypnotic, the dosage and perhaps duration of treatment. The detection of rebound requires both sleep-laboratory and clinical studies with night-by-night analyses of individual patient data. This review concentrates on the newer compounds, (quazepam and zolpidem) which act selectively on subtypes of benzodiazepine receptors or bind atypically (zopiclone). It concludes that present evidence, while limited, is consistent with claims of less rebound potential than older benzodiazepine hypnotics of equivalent duration of action. Nevertheless, further rigorous studies are essential before these claims can be totally accepted. Springer-Verlag, 1992 Rebound insomnia nationallicence Benzodiazepines nationallicence Quazepam nationallicence Zopiclone nationallicence Zolpidem nationallicence Psychopharmacology Springer-Verlag 108/3(1992-08-01), 248-255 0033-3158 108:3<248 1992 108 213 https://doi.org/10.1007/BF02245108 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245108 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lader Malcolm Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 248-255 0033-3158 108:3<248 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer