caa a22 4500 469119276 CHVBK 20180323133133.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245128 doi (NATIONALLICENCE)springer-10.1007/BF02245128 Slow wave sleep and 5-HT2 receptor sensitivity in generalised anxiety disorder: a pilot study with ritanserin [Elektronische Daten] [J. da Roza Davis, A. Sharpley, P. Cowen] Eight patients with generalised anxiety disorder (GAD) and eight matched healthy controls had their polysomnogram measured on two occasions separated by 1 week. On one occasion they received the 5-HT2 receptor antagonist, ritanserin (5 mg orally) and on the other matching placebo. The increase in slow wave sleep produced by ritanserin was the same in GAD patients as in healthy controls. These findings do not support the hypothesis that GAD is associated with a generalised hypersensitivity of brain 5-HT2 receptors; however, the present data cannot exclude the presence of a regionally specific change in this receptor subtype in anxiety disorders. Springer-Verlag, 1992 Anxiety nationallicence Slow wave sleep nationallicence Ritanserin nationallicence 5-HT2 receptor nationallicence da Roza Davis J. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Sharpley A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 387-389 0033-3158 108:3<387 1992 108 213 https://doi.org/10.1007/BF02245128 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- da Roza Davis J. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Sharpley A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 387-389 0033-3158 108:3<387 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer