caa a22 4500 469119284 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245125 doi (NATIONALLICENCE)springer-10.1007/BF02245125 MK-801 prevents the enhanced behavioural response to apomorphine elicited by repeated electroconvulsive treatment in mice [Elektronische Daten] [G. Nomikos, A. Mathé, J. Mathé, T. Svensson] Repeated administration of electroconvulsive stimuli (ECS) to mice once daily for a period of 7 days results in an enhanced locomotor response induced by apomorphine (1.0 mg/kg, IP). Pretreatment (30 min) with the N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801 (0.01-1.0 mg/kg IP), suppressed ECS-induced seizure activity in a dose-dependent manner. MK-801 (0.01 and 0.033 mg/kg, IP) given 30 min before each ECS dose-dependently decreased apomorphine-mediated responses. Administration of MK-801 (0.033 mg/kg IP) 30 min after each convulsion had the same effect. These results indicate that MK-801 can abolish the ECS-induced enhancement of dopamine-mediated behaviour possibly by interfering with postictal processes. Thus, NMDA receptors seem to be involved in the behavioural changes and presumably also in the neural adaptations produced by repeated ECS. Springer-Verlag, 1992 Electroconvulsive treatment nationallicence MK-801 nationallicence Apomorphine nationallicence Locomotor activity nationallicence Dopamine nationallicence NMDA receptor nationallicence Mice nationallicence Nomikos G. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut Mathé A. Department of Psychiatry at St Göran's Hospital, S-10401, Stockholm, Sweden aut Mathé J. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut Svensson T. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 367-370 0033-3158 108:3<367 1992 108 213 https://doi.org/10.1007/BF02245125 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245125 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nomikos G. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Mathé A. Department of Psychiatry at St Göran's Hospital, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Mathé J. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Svensson T. Department of Pharmacology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 367-370 0033-3158 108:3<367 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer