caa a22 4500 469119314 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245115 doi (NATIONALLICENCE)springer-10.1007/BF02245115 Effects of increasing response requirement on choice between cocaine and food in rhesus monkeys [Elektronische Daten] [Michael Nader, William Woolverton] Rhesus monkeys were trained in a discretetrials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule, the frequency of cocaine choice and the total drug intake increased in a dose-related manner for all monkeys. When the FR for cocaine was differentially increased, the frequency of cocaine choice decreased, shifting the cocaine dose-response function to the right and/or downward. When the FR for cocaine was at least 480, cocaine preference could not be recovered up to doses of 1.0 mg/kg/injection. In a second experiment, when the response requirement for food was differentially increased, the frequency of cocaine choice increased. These results demonstrate that altering the response requirement for cocaine or for alternative reinforcers that are available can substantially affect cocaine self-administration. Springer-Verlag, 1992 Discrete-trials choice nationallicence Self-administration nationallicence Cocaine nationallicence Progressive-ratio nationallicence Alternative reinforcer nationallicence Rhesus monkey nationallicence Nader Michael Department of Psychiatry, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut Woolverton William Department of Psychiatry, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 295-300 0033-3158 108:3<295 1992 108 213 https://doi.org/10.1007/BF02245115 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245115 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nader Michael Department of Psychiatry, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Woolverton William Department of Psychiatry, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 295-300 0033-3158 108:3<295 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer