caa a22 4500 469119322 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245127 doi (NATIONALLICENCE)springer-10.1007/BF02245127 Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man [Elektronische Daten] [P. Grasby, K. Friston, C. Bench, P. Cowen, C. Frith, P. Liddle, R. Frackowiak, R. Dolan] Repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of the 5-HT1A partial agonist, buspirone, or placebo. The difference in rCBF, before and after drug, (buspirone versus placebo) was used to identify brain areas affected by buspirone. Buspirone-induced changes in rCBF were studied under two behavioural conditions (5 word-list learning and 15 word-list learning). Compared to placebo, buspirone increased blood flow in the cuneus during both behavioural states. However, decreases in blood flow, centred in the left dorso-lateral prefrontal cortex and posterior cingulate cortex, were only observed under one of the two behavioural conditions. It is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-HT projections), but rather in relation to putative neuronal circuits possibly many synapses "downstream” of buspirone's pharmacological site of action. Springer-Verlag, 1992 Buspirone nationallicence 5-HT1A receptors nationallicence Positron emission tomography nationallicence Statistical parametric mapping nationallicence Pharmacological challenge nationallicence Grasby P. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Friston K. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Bench C. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Cowen P. MRC Clinical Pharmacology Unit, Littlemore Hospital, Littlemore, OX4 4XN, Oxford, UK aut Frith C. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Liddle P. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Frackowiak R. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Dolan R. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 380-386 0033-3158 108:3<380 1992 108 213 https://doi.org/10.1007/BF02245127 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245127 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grasby P. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Friston K. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Bench C. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Clinical Pharmacology Unit, Littlemore Hospital, Littlemore, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Frith C. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Liddle P. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Frackowiak R. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 700 1- Dolan R. MRC Cyclotron Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 380-386 0033-3158 108:3<380 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer