caa a22 4500 469119330 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245126 doi (NATIONALLICENCE)springer-10.1007/BF02245126 Differential effects of diazepam and lorazepam on repetition priming in healthy volunteers [Elektronische Daten] [François Sellal, Jean-Marie Danion, Françoise Kauffmann-Muller, Danielle Grangé, Jean-Louis Imbs, Martial Van Der Linden, Léonard Singer] The effects of two benzodiazepines, diazepam (15 or 20 mg orally) and lorazepam (1.75 or 2.5 mg orally), and a placebo on explicit memory, lexical priming and perceptual priming were assessed using a freerecall, a word-completion and a picture-completion test. The picture-completion test included two different study conditions intended to manipulate the magnitude of the priming effect. Sixty healthy volunteers took part in this double-blind study. Free-recall performances were altered by both drugs. Lorazepam impaired word-completion and picture-completion performance, whereas diazepam only exhibited a deleterious effect on the more sensitive of the two measures of the picture-completion test. These results indicate that the two benzodiazepines have differential amnestic effects. It is suggested that these differential effects could be accounted for by a different cortical distribution of the two benzodiazepines. Springer-Verlag, 1992 Benzodiazepines nationallicence Diazepam nationallicence Human nationallicence Lorazepam nationallicence Memory nationallicence Repetition priming nationallicence Sellal François Clinique Neurologique, Service de Neurologie I, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Danion Jean-Marie Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Kauffmann-Muller Françoise Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Grangé Danielle Centre de Calcul, C.N.R.S., 23, rue du Loess, F-67200, Strasbourg, France aut Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 rue Humann, F-67000, Strasbourg, France aut Van Der Linden Martial Unité de Neuropsychologie Cognitive, Université de Louvain, Faculté de Psychologie, Voie du Roman Pays, 20, B-1348, Louvain La Neuve, Belgium aut Singer Léonard Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 371-379 0033-3158 108:3<371 1992 108 213 https://doi.org/10.1007/BF02245126 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245126 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sellal François Clinique Neurologique, Service de Neurologie I, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Danion Jean-Marie Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Kauffmann-Muller Françoise Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Grangé Danielle Centre de Calcul, C.N.R.S., 23, rue du Loess, F-67200, Strasbourg, France aut NATIONALLICENCE 700 1- Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11 rue Humann, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Van Der Linden Martial Unité de Neuropsychologie Cognitive, Université de Louvain, Faculté de Psychologie, Voie du Roman Pays, 20, B-1348, Louvain La Neuve, Belgium aut NATIONALLICENCE 700 1- Singer Léonard Departement de Psychiatrie, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 371-379 0033-3158 108:3<371 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer