caa a22 4500 469119365 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245116 doi (NATIONALLICENCE)springer-10.1007/BF02245116 Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence [Elektronische Daten] [Nancy Ator, Roland Griffiths] Reinforcing and physical dependence-producing effects of oral diazepam and triazolam (0.01-1.28 mg/ml) were studied in four non-water-deprived baboons in daily 2-3-h sessions. Drinking initially was food-induced, but subsequently it was maintained for>year without the inducing procedures; drug intake>10 mg/kg per session was attained. Triazolam and diazepam reinforcement (compared to vehicle) was concluded for only one baboon for each drug under a single-spout procedure and for two baboons for each drug under a two-spout procedure. However, all baboons showed ethanol reinforcement under a two-spout procedure. When a lever-pressing requirement was imposed for each drink (one-spout procedure), ethanol maintained requirements of 128 or 256 responses/drink, and volume of ethanol consumed was greater than vehicle. Neither benzodiazepine maintained lever pressing better than vehicle at any response requirement and drinking was suppressed by requirements of 1-32. Physical dependence to triazolam and diazepam developed after approximately 1 month of daily ingestion, evidenced by a precipitated withdrawal syndrome after injection of the benzodiazepine antagonist flumazenil. A mild spontaneous withdrawal syndrome occurred after substitution of vehicle for triazolam or diazepam. These data indicate a clear dissociation between the reinforcing and physical dependence-producing effects of triazolam and diazepam. Springer-Verlag, 1992 Triazolam nationallicence Diazepam nationallicence Ethanol nationallicence Oral self-administration nationallicence Benzodiazepine physical dependence nationallicence Ator Nancy Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, 21224, Baltimore, MD, USA aut Griffiths Roland Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 301-312 0033-3158 108:3<301 1992 108 213 https://doi.org/10.1007/BF02245116 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245116 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ator Nancy Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Griffiths Roland Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 301-312 0033-3158 108:3<301 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer