caa a22 4500 469119381 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245111 doi (NATIONALLICENCE)springer-10.1007/BF02245111 Effects of repeated MK-801 on ambulation in mice and in sensitization following methamphetamine [Elektronische Daten] [Hisashi Kuribara, Takayasu Asami, Iturou Ida, Yukio Iijima, Sakutaro Tadokoro] The noncompetitive NMDA receptor antagonist MK-801, (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cyclohepten-5,10-imine, increased ambulatory activity in the mouse at doses over 0.1 mg/kg (IP). The effect was enhanced when 0.3 mg/kg MK-801 was repeatedly administered at intervals of 3-4 days. In contrast, a reduction of the effect was induced with repeated doses of 0.1 and 1 mg/kg. The mice that had repeatedly experienced 1 mg/kg MK-801 exhibited a decrease in the sensitivity to methamphetamine (2 mg/kg SC). In addition, the repeated co-administration of 1 mg/kg MK-801 with methamphetamine induced a decrease in the sensitivity to methamphetamine. No modification of methamphetamine sensitivity was elicited by 0.1 and 0.3 mg/kg MK-801 in both the single and co-administration schedules. On the other hand, established sensitization to methamphetamine was hardly affected by repeated treatment with 0.1-1 mg/kg MK-801. These results indicate that the mechanism of the inhibitory action of MK-801 on the development of methamphetamine sensitization is different from that of dopamine D2 antagonists, which may act to decrease the effective unit dose of methamphetamine and reduce ambulation-increasing effect of methamphetamine. Springer-Verlag, 1992 MK-801 nationallicence Ambulatory activity nationallicence Repeated administration nationallicence Methamphetamine sensitivity nationallicence Mice nationallicence Kuribara Hisashi Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut Asami Takayasu Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut Ida Iturou Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut Iijima Yukio Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut Tadokoro Sakutaro Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 271-275 0033-3158 108:3<271 1992 108 213 https://doi.org/10.1007/BF02245111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuribara Hisashi Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut NATIONALLICENCE 700 1- Asami Takayasu Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut NATIONALLICENCE 700 1- Ida Iturou Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut NATIONALLICENCE 700 1- Iijima Yukio Department of Neuropsychiatry, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut NATIONALLICENCE 700 1- Tadokoro Sakutaro Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine, 3-39-22 Showa-machi, 371, Maebashi, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 271-275 0033-3158 108:3<271 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer