caa a22 4500 469119403 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245123 doi (NATIONALLICENCE)springer-10.1007/BF02245123 MK-801 produces a reduction in anxiety-related antipredator defensiveness in male and female rats and a gender-dependent increase in locomotor behavior [Elektronische Daten] [D. Caroline Blanchard, Robert Blanchard, Antonio Carobrez, Rosemary Veniegas, R. John Rodgers, Jon Shepherd] The present study investigated the effects of the non-competitive NMDA antagonist MK-801 (0.04-0.16 mg/kg), on antipredator defensive reactions of male and female rats in three paradigms comprising the Anxiety/Defense Test Battery (A/DTB). In order to facilitate interpretation of data from the above study, the behavioral effects of the compound were also assessed in the non-threatening environment of the home cage. The data indicate a marked gender difference in the locomotor effects of the compound with females, but not males, showing a dose-dependent increase in general locomotor activity, a decrease in freezing, and a loss of balance at the highest dose, in both non-threatening and threatening contexts. The behavioral profile for males in the A/DTB included decreased orientation to and proxemic avoidance of the cat stimulus or stimulus site, and increased transits and eating in the cat situation. Contacts with the cat odor stimulus were increased, as was normal, curved back, locomotion in this test. In the absence of non-specific locomotor effects for males, this profile for the A/DTB provides convincing evidence for anxiety/fear reduction with MK-801. While locomotor effects tended to mask the putative anxiolytic properties of the compound in females, evidence remains from behavioral changes not attributable to a locomotor influence to indicate anxiety/fear reduction in this sex. Springer-Verlag, 1992 NMDA antagonist nationallicence MK-801 nationallicence Anxiety nationallicence Antipredator defense nationallicence Fear nationallicence Animal model nationallicence Sex differences nationallicence Locomotor activity nationallicence Caroline Blanchard D. Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut Blanchard Robert Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut Carobrez Antonio Departamento de Farmacologia, Universidade Federal de Santa Catarina, 88015, Florianopolis, SC, Brazil aut Veniegas Rosemary Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut John Rodgers R. Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut Shepherd Jon Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 352-362 0033-3158 108:3<352 1992 108 213 https://doi.org/10.1007/BF02245123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245123 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Caroline Blanchard D. Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Blanchard Robert Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Carobrez Antonio Departamento de Farmacologia, Universidade Federal de Santa Catarina, 88015, Florianopolis, SC, Brazil aut NATIONALLICENCE 700 1- Veniegas Rosemary Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- John Rodgers R. Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Shepherd Jon Bekesy Laboratory of Neurobiology, University of Hawaii, 96822, Honolulu, HI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 352-362 0033-3158 108:3<352 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer