caa a22 4500 469119446 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF02245122 doi (NATIONALLICENCE)springer-10.1007/BF02245122 Effects of chlorpromazine and lorazepam on explicit memory, repetition priming and cognitive skill learning in healthy volunteers [Elektronische Daten] [Jean-Marie Danion, Siegfried Peretti, Danielle Grangé, Miloslav Bilik, Jean-Louis Imbs, Léonard Singer] To assess the influence of neuroleptics on explicit memory and two forms of implicit memory, repetition priming and cognitive skill learning, the effects of two low doses of chlorpromazine (12.5 and 25 mg orally) were contrasted to those of lorazepam (2.5 mg orally) and of a placebo using a free-recall task, a word-completion task and repeated testing on the Tower of Toronto puzzle, a version of the Tower of Hanoi puzzle. Seventy-two healthy volunteers took part in this double-blind study. Chlorpromazine spared free-recall and word-completion performance, but impaired the acquisition of a cognitive routine in the subjects who completed the first trials of the Tower of Toronto puzzle efficiently. Lorazepam induced an opposite pattern of memory disruption. These preliminary results suggest that chlorpromazine and lorazepam induced a double dissociation between priming and the acquisition of a cognitive routine. They provide evidence that the two forms of implicit memory rely upon distinct neurochemical systems, the latter, but not the former, being dependent upon dopaminergic systems. Springer-Verlag, 1992 Chlorpromazine nationallicence Dopamine nationallicence Human nationallicence Learning nationallicence Lorazepam nationallicence Memory nationallicence Danion Jean-Marie Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Peretti Siegfried Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Grangé Danielle Unite de Statistiques, Centre de Calcul du CNRS, 23, rue du Loess, F-67200, Strasbourg, France aut Bilik Miloslav Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11, rue Humann, F-67000, Strasbourg, France aut Singer Léonard Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut Psychopharmacology Springer-Verlag 108/3(1992-08-01), 345-351 0033-3158 108:3<345 1992 108 213 https://doi.org/10.1007/BF02245122 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245122 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Danion Jean-Marie Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Peretti Siegfried Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Grangé Danielle Unite de Statistiques, Centre de Calcul du CNRS, 23, rue du Loess, F-67200, Strasbourg, France aut NATIONALLICENCE 700 1- Bilik Miloslav Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 700 1- Imbs Jean-Louis Institut de Pharmacologie, Unité de Pharmacologie Clinique, Faculté de Médecine, 11, rue Humann, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Singer Léonard Department of Psychiatry, Hôpitaux Universitaires, F-67091, Strasbourg Cedex, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/3(1992-08-01), 345-351 0033-3158 108:3<345 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer