caa a22 4500 469119500 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02247429 doi (NATIONALLICENCE)springer-10.1007/BF02247429 Nicotine intake and dependence in Swedish snuff takers [Elektronische Daten] [Herman Holm, Martin Jarvis, Michael Russell, Colin Feyerabend] Two studies examining nicotine intake in users of Swedish moist oral snuff are reported. Absorption form a single pinch (2 g) in ten users after overnight abstinence was fairly rapid. The increment in plasma nicotine concentrations averaged 9.9 ng/ml (SD 6.5) after 10 min and peaked at 14.5 ng/ml (SD 4.6) shortly after discarding at 30 min. Among groups of habitual snuff takers (n=27) and cigarette smokers (n=35) studied on a day of normal snuffing/smoking, peak blood nicotine levels after use were similar [averaging 36.6 ng/ml (SD 14.4) and 36.7 ng/ml (SD 16.1), respectively], but there was a tendency to higher cotinine levels in the snuffers (399.2 ng/ml versus 306.3 ng/ml). The snuff takers and cigarette smokers reported similar levels of subjective dependence on tobacco. Epidemiological study of Swedish snuff users could clarify whether the cardiovascular risks of tobacco are attributable to nicotine or to other smoke components, as in their case nicotine intake is not accompanied by combustion products. Springer-Verlag, 1992 Snuff nationallicence Nicotine nationallicence Cotinine nationallicence Dependence nationallicence Holm Herman Department of Psychiatry, Kalmar Hospital, S-Kalmar, Sweden aut Jarvis Martin ICRF Health Behaviour Unit, Institute of Psychiatry, 4, Windsor Walk, SE5 8AF, London, UK aut Russell Michael ICRF Health Behaviour Unit, Institute of Psychiatry, 4, Windsor Walk, SE5 8AF, London, UK aut Feyerabend Colin Poisons Unit, New Cross Hospital, London, UK aut Psychopharmacology Springer-Verlag 108/4(1992-09-01), 507-511 0033-3158 108:4<507 1992 108 213 https://doi.org/10.1007/BF02247429 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247429 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holm Herman Department of Psychiatry, Kalmar Hospital, S-Kalmar, Sweden aut NATIONALLICENCE 700 1- Jarvis Martin ICRF Health Behaviour Unit, Institute of Psychiatry, 4, Windsor Walk, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Russell Michael ICRF Health Behaviour Unit, Institute of Psychiatry, 4, Windsor Walk, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Feyerabend Colin Poisons Unit, New Cross Hospital, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/4(1992-09-01), 507-511 0033-3158 108:4<507 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer