caa a22 4500 469119551 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02247431 doi (NATIONALLICENCE)springer-10.1007/BF02247431 Controlled dosing of nicotine via an I ntranasal N icotine A erosol D elivery D evice (INADD) [Elektronische Daten] [Ovide Pomerleau, Karen Flessland, Cynthia Pomerleau, M. Hariharan] The present report describes anIntranasalNicotineAerosolDeliveryDevice (INADD) employing an artist's airbrush as aerosolizer and precise, electromechanical control of spray duration. It was designed for the administration of controlled doses of nicotine in a laboratory setting and has been used successfully in over 30 smokers and nonsmokers of both genders. In the present study, nicotine was administered to 12 male smokers at three different doses (0.05 mg, 1.00 mg, and 2.00 mg), and at the same dose (1 mg) on three different occasions. The low dose produced a minimal change in plasma nicotine, while the high dose produced a peak increment of around 16 ng/ml. The medium dose reliably produced a peak increment of around 8-9 ng/ml on all three occasions. Nicotine in plasma showed a sharp rise followed by a slower decline, mimicking the pattern associated with cigarette smoking. Physiological and biochemical responses showed significant dose-response relationships. Subjective reports suggested that aerosol dosing was somewhat aversive, but it is unclear whether this effect is intrinsic to the method or due to other factors. The device described in this report answers the need for a safe and easy means of controlling nicotine dose. Moreover, since nicotine administration via aerosol is novel for both smokers and non-smokers, minimizing the contributions of behavioral tolerance and habituation to the dosing vehicle, it lends itself to the comparison of the pharmacological effects of nicotine between experienced and naive subjects. Springer-Verlag, 1992 Aerosol nationallicence Nicotine nationallicence Controlled dosing nationallicence Cortisol response nationallicence Physiological response nationallicence Subjective response nationallicence Smokers nationallicence Pomerleau Ovide Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut Flessland Karen Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut Pomerleau Cynthia Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut Hariharan M. Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut Psychopharmacology Springer-Verlag 108/4(1992-09-01), 519-526 0033-3158 108:4<519 1992 108 213 https://doi.org/10.1007/BF02247431 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247431 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pomerleau Ovide Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Flessland Karen Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Pomerleau Cynthia Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Hariharan M. Department of Psychiatry, University of Michigan School of Medicine, Behavioral Medicine Program, Riverview Medical Building, 900 Wall Street, 48105, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/4(1992-09-01), 519-526 0033-3158 108:4<519 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer