caa a22 4500 46911956X CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02247424 doi (NATIONALLICENCE)springer-10.1007/BF02247424 Smoking, nicotine dose and the lateralisation of electrocortical activity [Elektronische Daten] [Royan Norton, Kenneth Brown, Rick Howard] The effects of cigarette smoking on the balance of activity of the cerebral hemispheres were studied in two experiments. Experiment 1 examined the effects of smoking on lateralisation of EEG alpha and beta power in six male smokers, and revealed a dose-related biphasic action. Low doses of nicotine as measured by residual butt analysis increased left hemisphere activity in a dose related manner, while higher doses (>1.1 mg) reversed this effect. Experiment 2 examined the time course of the changes in EEG alpha, beta, theta and delta lateralisation in 11 male smokers. During the initial period of smoking there was a reduction in EEG alpha, reflecting cortical activation, followed by an increase in alpha power towards the end of the cigarette. These changes were accompanied in smokers taking moderate nicotine doses, by an initial shift towards left hemisphere activation, followed by a reduction in left hemisphere activation relative to the right. Initial changes in delta and theta power were negatively correlated with nicotine dose. Higher nicotine doses were associated with greater shifts towards right hemisphere activation, as indicated by beta and delta lateralisation, and also with greater decreases in subjective arousal. These results were interpreted as supporting the hypothesis that the stimulant action of lower doses of nicotine involves the activation of a left hemisphere "Go” system, while the sedative effect of higher doses involves increased activation of the right hemisphere "NoGo” system. Springer-Verlag, 1992 Nicotine nationallicence Smoking nationallicence EEG nationallicence Lateralisation nationallicence Norton Royan School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut Brown Kenneth School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut Howard Rick School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut Psychopharmacology Springer-Verlag 108/4(1992-09-01), 473-479 0033-3158 108:4<473 1992 108 213 https://doi.org/10.1007/BF02247424 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247424 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Norton Royan School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Brown Kenneth School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Howard Rick School of Psychology, The Queen's University of Belfast, BT7 1NN, Belfast, Northern Ireland, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/4(1992-09-01), 473-479 0033-3158 108:4<473 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer