caa a22 4500 469119594 CHVBK 20180323133134.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02247415 doi (NATIONALLICENCE)springer-10.1007/BF02247415 Levin Edward Nicotine Research Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3557, 27710, Durham, NC, USA aut Nicotinic systems and cognitive function [Elektronische Daten] [Edward Levin] Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia. Springer-Verlag, 1992 Acetylcholine nationallicence Nicotinic nationallicence Memory nationallicence Nicotine nationallicence Mecamylamine nationallicence Psychopharmacology Springer-Verlag 108/4(1992-09-01), 417-431 0033-3158 108:4<417 1992 108 213 https://doi.org/10.1007/BF02247415 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247415 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Levin Edward Nicotine Research Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3557, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/4(1992-09-01), 417-431 0033-3158 108:4<417 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer