caa a22 4500 469119659 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02247423 doi (NATIONALLICENCE)springer-10.1007/BF02247423 Psychopharmacological effects of smoking a cigarette with typical "tar” and carbon monoxide yields but minimal nicotine [Elektronische Daten] [John Robinson, Walter Pritchard, Riley Davis] Five male smokers were tested, after 48-h abstention from tobacco-product use, smoking a leading "lights” category cigarette (Control — FTC nicotine yield 0.6 mg) and another cigarette yielding similar amounts of "tar” and carbon monoxide (CO), but only 0.06 mg nicotine (Test). Heart rate (HR) and the electroencephalogram (EEG) were monitored before, during and after the smoking of each cigarette. Other measures obtained included the subjects' puffing and breathing behaviors during smoking, plasma nicotine concentrations, blood carboxyhemoglobin concentrations and expired-air CO. The results indicated no significant differences in the way the subjects puffed and inhaled the two cigarettes and they were therefore assumed to have inhaled similar amounts of particulate matter and gasphase components. Plasma nicotine concentrations were significantly higher following smoking of the Control cigarette. HR (percent relative change) increased following smoking of either cigarette; however, HR increase was significantly greater following smoking of the Control cigarette. Smoking the Test cigarette had no effect on the EEG. Smoking the Control cigarette produced a significant increase in beta2 magnitude and a significant decrease in delta magnitude. This indicates that the effects of smoking on the EEG are a function of nicotine absorbed from cigarette smoke upon inhalation and not a function of inhaled particulate matter, CO, or other gas-phase components. Springer-Verlag, 1992 Tar nationallicence Carbon monoxide nationallicence Nicotine nationallicence Psychopharmacological effects nationallicence Robinson John Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut Pritchard Walter Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut Davis Riley Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut Psychopharmacology Springer-Verlag 108/4(1992-09-01), 466-472 0033-3158 108:4<466 1992 108 213 https://doi.org/10.1007/BF02247423 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247423 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Robinson John Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Pritchard Walter Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut NATIONALLICENCE 700 1- Davis Riley Biobehavioral R & D, R.J. Reynolds Tobacco Company, Reynolds Boulevard, 27102, Winston-Salem, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/4(1992-09-01), 466-472 0033-3158 108:4<466 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer