caa a22 4500 469119675 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245289 doi (NATIONALLICENCE)springer-10.1007/BF02245289 Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction [Elektronische Daten] [Jane Stewart, Roy Wise] The effects of morphine, naltrexone, and nalorphine were studied in rats trained to lever-press for intravenous heroin and then tested under conditions of non-reinforcement. Animals were reinforced for lever-pressing on a continuous reinforcement schedule (100 µg/kg per infusion) for 2-3 h each day following which reinforcement was terminated and animals were studied under extinction conditions for the remainder of the session. Each day following the termination of responding under extinction conditions, animals were given a single injection of saline, morphine, nalorphine, or naltrexone; lever-pressing under the extinction conditions was then observed for several hours. When animals adapted to this regimen, very low levels of responding were seen following saline injections; morphine (2 or 10 mg/kg) reinstated vigorous responding that lasted 1-4 h. Naltrexone (2 mg/kg) suppressed responding below the levels seen after saline, and nalorphine (10 mg/kg) had the same effect as saline. These observations support the view that opioid-seeking behavior is primed by the proponent or opioid-like actions of opioids and not by the opponent or drug-opposite effects associated with opioid withdrawal. Springer-Verlag, 1992 Opioids nationallicence Self-administration nationallicence Reinstatement nationallicence Proponent process nationallicence Opponent process nationallicence Naltrexon nationallicence Relapse nationallicence Stewart Jane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut Wise Roy Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 79-84 0033-3158 108:1-2<79 1992 108 213 https://doi.org/10.1007/BF02245289 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stewart Jane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Wise Roy Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 79-84 0033-3158 108:1-2<79 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer