caa a22 4500 469119691 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245288 doi (NATIONALLICENCE)springer-10.1007/BF02245288 Delayed-non-match-to-sample performance in the radial arm maze: effects of dopaminergic and gabaergic agents [Elektronische Daten] [James Chrobak, T. Napier] Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpirole (D2 agonist; 0.1 mg/kg), or SKF38393 (D1 agonist; 3 mg/kg) increased the latency of choices but did not affect any index of accuracy with a 1 h retention interval. Post-training administration of quinpirole (0.1, 0.2, 1.0, and 2.0 mg/kg), SKF38393 (0.3, 3.0, and 6.0 mg/kg), sulpiride (D2 antagonist; 3, 10, and 30 mg/kg), or SCH23390 (D1 antagonist; 0.01, 0.1, and 1.0 mg/kg) also did not affect accuracy, although quinpirole produced a dose-dependent increase in the latency of choices, assessed 10 h post-treatment. For comparison, pretraining and post-training administration of the benzodiazepine chlordiazepoxide (1, 3, 5 mg/kg) was also tested and produced dose-dependent impairments in mnemonic performance at either a 1 or 4 h retention interval. The effects of chlordiazepoxide are consistent with evidence indicating that GABAergic agents can influence memory processes. In contrast, the present findings indicate that (peripheral administration of dopaminergic agents IS) not sufficient to alter the mnemonic processes required for accurate performance of this DNMTS-RAM task. Springer-Verlag, 1992 Working/episodic memory nationallicence Radial arm maze nationallicence Non-match-to-sample task nationallicence Dopamine nationallicence Apomorphine nationallicence Quinpirole nationallicence SKF38393 nationallicence Sulpiride nationallicence SCH23390 nationallicence Benzodiazepine nationallicence Chlordiazepoxide nationallicence Chrobak James Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, 60153, Maywood, IL, USA aut Napier T. Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, 60153, Maywood, IL, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 72-78 0033-3158 108:1-2<72 1992 108 213 https://doi.org/10.1007/BF02245288 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chrobak James Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, 60153, Maywood, IL, USA aut NATIONALLICENCE 700 1- Napier T. Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, 60153, Maywood, IL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 72-78 0033-3158 108:1-2<72 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer