caa a22 4500 469119713 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245298 doi (NATIONALLICENCE)springer-10.1007/BF02245298 Differential ethanol intake in Tryon maze-bright and Tryon maze-dull rats: implications for the validity of the animal model of selectively bred rats for high ethanol consumption [Elektronische Daten] [Zalman Amit, Brian Smith] The search for a genetically based "animal model of alcoholism” has led to the creation of extensive research programs using various combinations of initial ethanol preference screening techniques and breeding methods to yield rodents with primary genetic differences that contribute to high or low ethanol preference. The present experiment examined the ethanol intake of the Tryon rat strain, which were bred for high and low maze learning scores. It was observed that the Tryon Maze Bright rats displayed an unprecedented affinity for ethanol with stable intakes between 12.7 and 13.7 g/kg per day and preference ratios exceeding 0.75 for ethanol concentrations ranging between 15 and 29%. The pattern of ethanol intake of the Tryon Maze Dull rats resembled the ethanol intake pattern of other, non-selectively bred strains of rats, approximately 2-3 g/kg of absolute ethanol at preference ratios between 0.11 and 0.28. The affinity for ethanol observed for the Tryon Maze Bright rats seems to exceed the reported consumption patterns of rat strains specifically bred for high ethanol consumption although the Tryon rats were selectively bred for variables that were seemingly unrelated to ethanol intake. Springer-Verlag, 1992 Tryon rats nationallicence Ethanol intake nationallicence Selective breeding nationallicence Genetic nationallicence Animal model of alcoholism nationallicence Amit Zalman Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, H-1013, H3G 1M8, Montreal, Quebec, Canada aut Smith Brian Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, H-1013, H3G 1M8, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 136-140 0033-3158 108:1-2<136 1992 108 213 https://doi.org/10.1007/BF02245298 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245298 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amit Zalman Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, H-1013, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Smith Brian Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, H-1013, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 136-140 0033-3158 108:1-2<136 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer