caa a22 4500 469119721 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245305 doi (NATIONALLICENCE)springer-10.1007/BF02245305 FG 7142 selectively decreases nonpunished responding, but has no anxiogenic effects on time allocation in a conflict schedule [Elektronische Daten] [L. Panlilio, S. Weiss, D. Thomas, J. Glowa] Previous work (Thomas et al. 1990) showed that an anxiolytic benzodiazepine increased the time allocated to responding in a conflict situation (where responses were both food-reinforced and shock-punished) versus a nonpunishment situation. The present experiment tested whether a benzodiazepine-receptor inverse agonist (FG 7142, 1-30 mg/kg) would have the opposite effect (i.e., decrease time spent responding in a punishment situation). Chain pulls determined whether a rat's lever presses were reinforced on 1) a lean variable-interval schedule, or 2) a richer variable-interval schedule in which responding also produced shock intermittently. FG 7142 dose-dependently decreased nonpunished lever responding, but did not affect punished responding. The drug nonselectively decreased chain pulling (the schedule-switching response). Like chlordiazepoxide, FG 7142 increased the time spent in the punishment component, showing that not all effects of benzodiazepine-receptor agonists and inverse agonists are opposite. These results are inconsistent with expectations that anxiogenic actions of FG 7142 should 1) decrease punished responding; 2) increase the rate of responses that terminate the punishment condition; and 3) decrease time spent in the punishment component. Rather, nonsuppressed responding seems most sensitive to decreases by FG 7142. Springer-Verlag, 1992 Conflict schedule nationallicence FG 7142 nationallicence Inverse agonist nationallicence Punishment nationallicence Rat nationallicence Panlilio L. Department of Psychology, The American University, 20016, Washington, DC, USA aut Weiss S. Department of Psychology, The American University, 20016, Washington, DC, USA aut Thomas D. Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Building 30, Room B20, 20892, Bethesda, MD, USA aut Glowa J. Biopsychology Unit, Clinical Neuroendocrinology Branch, National Institute of Mental Health, B 14D, Room 311, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 185-188 0033-3158 108:1-2<185 1992 108 213 https://doi.org/10.1007/BF02245305 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245305 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Panlilio L. Department of Psychology, The American University, 20016, Washington, DC, USA aut NATIONALLICENCE 700 1- Weiss S. Department of Psychology, The American University, 20016, Washington, DC, USA aut NATIONALLICENCE 700 1- Thomas D. Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Building 30, Room B20, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Glowa J. Biopsychology Unit, Clinical Neuroendocrinology Branch, National Institute of Mental Health, B 14D, Room 311, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 185-188 0033-3158 108:1-2<185 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer