caa a22 4500 46911973X CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245278 doi (NATIONALLICENCE)springer-10.1007/BF02245278 Elevated corticosteroid levels block the memory-improving effects of nootropics and cholinomimetics [Elektronische Daten] [Cesare Mondadori, Thomas Ducret, Albert Häusler] Oral pretreatment of mice with aldosterone or corticosterone blocked the memory-enhancing effects of piracetam, pramiracetam, aniracetam and oxiracetam in a dose-related manner, without, however, impairing the animals' learning performance. The improvement of memory induced by physostigmine, arecoline, and tacrine (THA) was similarly inhibited. The fact that elevated steroid levels suppress the memory-enhancing effects of entirely different substances could indicate that these substances have a common site of action. In the light of new observations showing increased cortisol concentrations in Alzheimer patients, this steroid dependency of the effects of memory enhancers might explain why only a limited number of these patients respond to therapy with nootropics or cholinomimetics. Springer-Verlag, 1992 Nootropics nationallicence Cholinomimetics nationallicence Corticosteroids nationallicence Memory improvement nationallicence Mondadori Cesare Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut Ducret Thomas Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut Häusler Albert Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 11-15 0033-3158 108:1-2<11 1992 108 213 https://doi.org/10.1007/BF02245278 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245278 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mondadori Cesare Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut NATIONALLICENCE 700 1- Ducret Thomas Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut NATIONALLICENCE 700 1- Häusler Albert Pharmaceutical Research Department, K 125.1157, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 11-15 0033-3158 108:1-2<11 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer