caa a22 4500 469119764 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245312 doi (NATIONALLICENCE)springer-10.1007/BF02245312 Effect of m-chlorophenylpiperazine on plasma arginine-vasopressin concentrations in healthy subjects [Elektronische Daten] [René Kahn, Mitchel Kling, Scott Wetzler, Gregory Asnis, Herman van Praag] It has been demonstrated convincingly that ACTH and prolactin release are under the stimulatory control of serotonin (5-hydroxytryptamine, 5HT). Recent animal studies suggest that stimulation of 5HT activity also induces the release of arginine-vasopressin (AVP). More specifically, m-chlorophenylpiperazine (MCPP), a 5HT agonist widely used to examine 5HT receptor responsivity in human subjects, has been found to induce AVP release in rodents. This study examined whether MCPP increased plasma AVP levels in healthy human subjects. MCPP was administered orally to 17 healthy subjects in a placebo-controlled design in doses of 0.25 and 0.5 mg/kg. AVP was measured twice hourly over a 210 min period after administration of capsules. MCPP did not significantly alter AVP levels as compared to placebo. However, female subjects had significantly lower plasma AVP levels than males. Since it has been suggested that MCPP-induced AVP release in animals is due to stimulation of 5HT1c receptors, the fact that MCPP did not induce the release of AVP in humans suggests that either MCPP is not a potent 5HT1c agonist or that AVP is not released by stimulation of 5HT(1c) receptors in human subjects. The observation of gender differences in plasma AVP levels suggests that this factor should be taken into account in future studies of AVP secretion in plasma. Springer-Verlag, 1992 Serotonin nationallicence Arginine-vasopressin nationallicence m-Chlorophenylpiperazine nationallicence Human nationallicence Kahn René Department of Psychiatry, Mount Sinai Hospital/School of Medicine and the Bronx Veterans Administration Hospital, 140 West Kingsbridge Road, 10468, Bronx, NY, USA aut Kling Mitchel Clinical Neuroendocrinology Branch, N.I.M.H., Building 10, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Wetzler Scott Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Asnis Gregory Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut van Praag Herman Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 225-228 0033-3158 108:1-2<225 1992 108 213 https://doi.org/10.1007/BF02245312 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245312 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kahn René Department of Psychiatry, Mount Sinai Hospital/School of Medicine and the Bronx Veterans Administration Hospital, 140 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Kling Mitchel Clinical Neuroendocrinology Branch, N.I.M.H., Building 10, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wetzler Scott Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- Asnis Gregory Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 700 1- van Praag Herman Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 225-228 0033-3158 108:1-2<225 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer