caa a22 4500 469119772 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245291 doi (NATIONALLICENCE)springer-10.1007/BF02245291 Serotonergic function during lithium augmentation of refractory depression [Elektronische Daten] [Elinore McCance-Katz, Lawrence Price, Dennis Charney, George Heninger] Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IVl-tryptophan (l-TRP). We used thel-TRP test to assess the role of serotonin in the mechanism of action of lithium augmentation in refractory major depression. Twenty-six patients with antidepressant-refractory major depression each received threel-TRP tests (after 2 weeks of placebo, after 4 weeks of active primary antidepressant, and after 1 week of lithium augmentation). Primary antidepressant treatment did not increase the PRL response, but lithium augmentation resulted in a statistically significant increase in PRL response as compared to both placebo pretreatment (P<0.04) and antidepressant treatment alone (P<0.025). This study supports a role for serotonergic mechanisms in the action of lithium augmentation. Springer-Verlag, 1992 Antidepressants nationallicence Depression nationallicence Lithium nationallicence Serotonin nationallicence McCance-Katz Elinore Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut Price Lawrence Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut Charney Dennis Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut Heninger George Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 93-97 0033-3158 108:1-2<93 1992 108 213 https://doi.org/10.1007/BF02245291 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245291 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCance-Katz Elinore Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut NATIONALLICENCE 700 1- Price Lawrence Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut NATIONALLICENCE 700 1- Charney Dennis Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut NATIONALLICENCE 700 1- Heninger George Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, CT, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 93-97 0033-3158 108:1-2<93 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer