caa a22 4500 469119780 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245294 doi (NATIONALLICENCE)springer-10.1007/BF02245294 Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray [Elektronische Daten] [Simon Beckett, Andrew Lawrence, Charles Marsden, Paul Marshall] The ability of 5-HT1 receptor agonists to modulate a chemically induced defence response has been studied in Lister hooded rats. Microinjections of the excitatory amino acidd,l-homocysteic acid (DLH) in both rostral and caudal dorsal periaqueductal gray matter (PAG) caused explosive motor behaviour characteristic of defence. This behaviour was quantified in terms of response duration, arena revolutions and number of defensive jumps. Direct administration into the PAG of either 5-carboxamidotryptamine (5-CT) or 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT) produced behaviours (decreased exploratory rearing, dose related onset of flat body posture) indicative of 5-HT1A receptor activation. Pretreatment with either 5-CT or 8-OHDPAT directly in the PAG caused a significant attenuation, and in some cases a complete abolition, of the DLH evoked response. These agonists share high affinity in vitro for the 5-HT1A receptor. Thus the results suggest that in vivo activation of 5-HT1A receptors mediates an antiaversive reponse with respect to defensive behaviour elicited by specific chemical stimulation of the dorsal PAG. Springer-Verlag, 1992 Excitatory amino acid nationallicence Serotonin nationallicence Aversion nationallicence Periaqueductal gray nationallicence 5-HT1A receptor nationallicence Beckett Simon Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK aut Lawrence Andrew Pain Relief Foundation, Rice Lane, L9 1AE, Liverpool, UK aut Marsden Charles Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK aut Marshall Paul ICI Pharmaceuticals, Bioscience II, Mereside, Alderley Park, Macclesfield, Cheshire, UK aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 110-114 0033-3158 108:1-2<110 1992 108 213 https://doi.org/10.1007/BF02245294 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245294 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beckett Simon Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK aut NATIONALLICENCE 700 1- Lawrence Andrew Pain Relief Foundation, Rice Lane, L9 1AE, Liverpool, UK aut NATIONALLICENCE 700 1- Marsden Charles Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK aut NATIONALLICENCE 700 1- Marshall Paul ICI Pharmaceuticals, Bioscience II, Mereside, Alderley Park, Macclesfield, Cheshire, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 110-114 0033-3158 108:1-2<110 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer