caa a22 4500 469119799 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245303 doi (NATIONALLICENCE)springer-10.1007/BF02245303 Differential effects of early stimulation and/or perinatal flumazenil treatment in young Roman low- and high-avoidance rats [Elektronische Daten] [A. Fernández-Teruel, R. Escorihuela, P. Driscoll, A. Tobeña, K. Bättig] The effect of infantile handling-stimulation and/or perinatal flumazenil (3.7 mg/kg/day) administration on exploratory and emotional-related behavior was investigated using Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats. Postnatal handling increased exploration in 30-day-old rats of both psychogenetically selected lines when they were exposed to a hexagonal tunnel maze including an illuminated central arena. Likewise, postnatal stimulation decreased emotional reactivity in both lines of rats, as expressed by increased entry into the central arena, decreased defection and vocalization frequency, but these effects were more pronounced in the RLA/Verh line. There were interactions between perinatal flumazenil treatment and rat line, indicating that flumazenil enhanced entry into the maze central arena in handled-RLA/Verh rats, whereas a tendency toward the opposite effect was observed in drug-treated and handled-RHA/Verh animals. Thus, the present study emphasizes that the effects of environmental manipulations are partly dependent upon genetic factors, and that pharmacological effects also depend on both genetic and environmentally-induced predisposition. Springer-Verlag, 1992 Infantile stimulation nationallicence Roman high- and low-avoidance rats nationallicence Perinatal flumazenil (Ro15-1788) nationallicence Exploration nationallicence Emotional reactivity nationallicence Fernández-Teruel A. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut Escorihuela R. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut Driscoll P. Laboratorium für vergleichende Physiologie und Verhaltensbiologie, ETH-Zentrum, Turnerstrasse 1, CH-8092, Zurich, Switzerland aut Tobeña A. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut Bättig K. Laboratorium für vergleichende Physiologie und Verhaltensbiologie, ETH-Zentrum, Turnerstrasse 1, CH-8092, Zurich, Switzerland aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 170-176 0033-3158 108:1-2<170 1992 108 213 https://doi.org/10.1007/BF02245303 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245303 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-Teruel A. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Escorihuela R. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Driscoll P. Laboratorium für vergleichende Physiologie und Verhaltensbiologie, ETH-Zentrum, Turnerstrasse 1, CH-8092, Zurich, Switzerland aut NATIONALLICENCE 700 1- Tobeña A. Medical Psychology Unit, Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, E-08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Bättig K. Laboratorium für vergleichende Physiologie und Verhaltensbiologie, ETH-Zentrum, Turnerstrasse 1, CH-8092, Zurich, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 170-176 0033-3158 108:1-2<170 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer