caa a22 4500 469119802 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245297 doi (NATIONALLICENCE)springer-10.1007/BF02245297 Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice [Elektronische Daten] [J. Voigt, E. Morgenstern] Four antiepileptic drugs were investigated in an inhibitory avoidance task in mice. Following IP administration 30 min prior to training, carbamazepine (32 mg/kg), phenytoin (30-60 mg/kg), diazepam (2-8 mg/kg) and clonazepam (0.125-0.5 mg/kg) impaired retention. When administered 30 min prior to the retention test none of the drugs under investigation affected retention. The drugs did not affect latencies in the hot plate test. This indicates that in the case of pretraining drug administration effects on retention cannot attributed to elevated pain thresholds. Carbamazepine and phenytoin impaired avoidance learning at doses above those which prevent electroshock induced tonic hindlimb convulsions. Diazepam and clonazepam were effective at lower than anticonvulsant doses. The results of the study are relevant to the evaluation of CNS side effects of antiepileptic drugs in mice. Springer-Verlag, 1992 Mice nationallicence Antiepileptic drugs nationallicence Inhibitory avoidance learning nationallicence Carbamazepine nationallicence Clonazepam nationallicence Diazepam nationallicence Phenytoin nationallicence Voigt J. Pharmakologische Forschungsgesellschaft, Biopharm GmbH, Alfred-Kowalke-Strasse 4, O-1136, Berlin, Federal Republic of Germany aut Morgenstern E. Pharmakologische Forschungsgesellschaft, Biopharm GmbH, Alfred-Kowalke-Strasse 4, O-1136, Berlin, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 131-135 0033-3158 108:1-2<131 1992 108 213 https://doi.org/10.1007/BF02245297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Voigt J. Pharmakologische Forschungsgesellschaft, Biopharm GmbH, Alfred-Kowalke-Strasse 4, O-1136, Berlin, Federal Republic of Germany aut NATIONALLICENCE 700 1- Morgenstern E. Pharmakologische Forschungsgesellschaft, Biopharm GmbH, Alfred-Kowalke-Strasse 4, O-1136, Berlin, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 131-135 0033-3158 108:1-2<131 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer