caa a22 4500 469119810 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245306 doi (NATIONALLICENCE)springer-10.1007/BF02245306 Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats [Elektronische Daten] [N. Swerdlow, S. Caine, M. Geyer] Systemic administration of dopamine (DA) agonists markedly disrupts sensorimotor gating in rats as measured by prepulse inhibition (PPI) of the acoustic startle response. A qualitatively similar, but quantitatively weaker disruption of PPI follows DA infusion into the nucleus accumbens (NAC). The present study was designed to determine whether forebrain DA terminal fields other than the NAC contribute to the DAergic modulation of PPI. PPI was impaired significantly after infusion of DA (0-40 µg) into the NAC or anteromedial striatum, but not after DA infusion into the orbital cortex or posterolateral striatum. DA infusion into the amygdala also disrupted PPI, but this disruption was accompanied by a dose-dependent decrease in startle amplitude. These results suggest that DA overactivity in the both NAC and anteromedial striatum contribute to the gating-disruptive effects of systemically administered DA agonists, and that DA overactivity in mesocortical, mesoamygdaloid and "non-limbic” mesostriatal DA systems are not major substrates for a DAergic modulation of PPI. Springer-Verlag, 1992 Acoustic startle response nationallicence Amygdala nationallicence Dopamine nationallicence Nucleus accumbens nationallicence Orbital cortex nationallicence Prepulse inhibition nationallicence Sensorimotor gating nationallicence Striatum nationallicence Swerdlow N. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut Caine S. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut Geyer M. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 189-195 0033-3158 108:1-2<189 1992 108 213 https://doi.org/10.1007/BF02245306 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245306 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swerdlow N. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Caine S. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Geyer M. 0804, Department of Psychiatry, School of Medicine, University of California, 92093-0804, San Diego, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 189-195 0033-3158 108:1-2<189 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer