caa a22 4500 469119837 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245287 doi (NATIONALLICENCE)springer-10.1007/BF02245287 Rebound insomnia in normals and patients with insomnia after abrupt and tapered discontinuation [Elektronische Daten] [Timothy Roehrs, Lori Merlotti, Frank Zorick, Thomas Roth] Rebound insomnia was studied in subjects, aged 25-50 years, with insomnia complaints and normal sleep, insomnia complaints and disturbed sleep, and normal sleep with no complaints (N=21,n=7 per group). Standard sleep recordings were collected on a baseline night and after abrupt discontinuation of 6 nights of 0.50 mg triazolam, tapered discontinuation (3 nights of 0.50 mg, 2 nights of 0.25 mg, and 1 night of 0.125 mg triazolam) and 6 nights of placebo. Significantly disturbed sleep on the discontinuation night compared to the baseline night was found. The relative degree of rebound insomnia was greater in the abrupt condition than in either the tapered or placebo conditions. The tapered condition reduced sleep time by half that of the abrupt condition which was twice the reduction found in the placebo condition. An overall (regardless of group or condition) difference in baseline versus discontinuation sleep was found, suggesting that pill discontinuation itself leads to sleep disturbance. Subjects did not differ in rebound insomnia as a function of pre-existing sleep disturbance. Springer-Verlag, 1992 Insomnia nationallicence Triazolam nationallicence Individuality nationallicence Substance withdrawal syndrome nationallicence Sleep nationallicence Rebound insomnia nationallicence Roehrs Timothy Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Merlotti Lori Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Zorick Frank Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Roth Thomas Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 67-71 0033-3158 108:1-2<67 1992 108 213 https://doi.org/10.1007/BF02245287 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245287 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roehrs Timothy Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Merlotti Lori Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Zorick Frank Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Roth Thomas Henry Ford Hospital, Sleep Disorders and Research Center, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 67-71 0033-3158 108:1-2<67 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer