caa a22 4500 469119845 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245300 doi (NATIONALLICENCE)springer-10.1007/BF02245300 Pharmacological dissociation between the spatial learning deficits produced by morphine and diazepam [Elektronische Daten] [Robert McNamara, Ronald Skelton] This study sought to determine whether the place learning deficits produced by diazepam are a secondary result of opioid release. Rats pretreated with diazepam (3 mg/kg) or morphine (15 mg/kg) were trained in the Morris water maze. Diazepam impaired place learning-slowing acquisition and preventing the formation of a quadrant preference. Morphine also slowed acquisition, but did not prevent place learning, and impaired escape to a visible platform. Flumazenil blocked the deficits produced by diazepam, but not morphine. Naloxone (2 mg/kg) blocked the deficits produced by morphine, but not diazepam. A high dose of naloxone (10 mg/kg) slowed acquisition, and exacerbated the deficit produced by diazepam. These results demonstrate that diazepam interferes with mnemonic processes through endogenous benzodiazepine receptors, independently of opioidergic systems. Further, they suggest that morphine interferes with motivational processes through opioidergic systems, independently of endogenous benzodiazepine systems. Springer-Verlag, 1992 Diazepam nationallicence Morphine nationallicence Naloxone nationallicence Flumazenil nationallicence Place learning nationallicence Cue learning nationallicence Morris water maze nationallicence Benzodiazepines nationallicence Opioids nationallicence Rat nationallicence McNamara Robert Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B.C., Canada aut Skelton Ronald Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B.C., Canada aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 147-152 0033-3158 108:1-2<147 1992 108 213 https://doi.org/10.1007/BF02245300 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245300 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McNamara Robert Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B.C., Canada aut NATIONALLICENCE 700 1- Skelton Ronald Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B.C., Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 147-152 0033-3158 108:1-2<147 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer