caa a22 4500 469119888 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245284 doi (NATIONALLICENCE)springer-10.1007/BF02245284 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists [Elektronische Daten] [P. Simon, B. Guardiola, J. Bizot-Espiard, P. Schiavi, J. Costentin] The new compound (+) S-20499, an amino chromane derivative (8[-4[N-(5-methoxychromane-3yl)N-propyl]aminobutyl] azaspiro[4-5] décane-7,9 dione), is a high affinity full 5-HT1A agonist. We have investigated its effects on dopaminergic transmission. (+) S-20499 displayed a 10−8 M affinity for D2 dopamine (DA) receptors, 100 fold lower than for 5-HT1A receptors. The hypothermic effect of the drug was reversed by haloperidol in mice, suggesting that it behaves as a direct dopamine agonist. However, increasing doses of (+) S-20499 induced neither yawning nor penile erections, which constitute characteristic responses of direct DA agonists administered at low doses. In addition, (+) S-20499 prevented the apomorphine (100 µg/kg SC) induced yawning and penile erections. This inhibition appears to result from the stimulation of 5-HT1A receptors since it is an effect shared by both buspirone (from 5 mg/kg) and 8-OH-DPAT (from 0.10 mg/kg). In addition, when rats are treated with the 5-HT1A receptor antagonist tertatolol (2-5 mg/kg; SC), increasing doses of (+) S-20499 elicit the expected yawns and penile erections. It is concluded that the 5-HT1A agonist property opposes to that of D2 dopamine receptor stimulation with regard to yawning and penile erections. Springer-Verlag, 1992 Yawning nationallicence Penile erections nationallicence (+) S-20499 nationallicence 5-HT1A agonists nationallicence D2 receptors nationallicence Apomorphine nationallicence Rat nationallicence Simon P. Unité de Neuropsychopharmacologie, U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Avenue de l'Université, F-76803, Saint Etienne du Rouvray, France aut Guardiola B. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut Bizot-Espiard J. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut Schiavi P. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut Costentin J. Unité de Neuropsychopharmacologie, U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Avenue de l'Université, F-76803, Saint Etienne du Rouvray, France aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 47-50 0033-3158 108:1-2<47 1992 108 213 https://doi.org/10.1007/BF02245284 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245284 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simon P. Unité de Neuropsychopharmacologie, U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Avenue de l'Université, F-76803, Saint Etienne du Rouvray, France aut NATIONALLICENCE 700 1- Guardiola B. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut NATIONALLICENCE 700 1- Bizot-Espiard J. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut NATIONALLICENCE 700 1- Schiavi P. Iris-Servier, 6 place des Pléïades, F-92415, Courbevoie, France aut NATIONALLICENCE 700 1- Costentin J. Unité de Neuropsychopharmacologie, U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Avenue de l'Université, F-76803, Saint Etienne du Rouvray, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 47-50 0033-3158 108:1-2<47 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer