caa a22 4500 469119896 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245314 doi (NATIONALLICENCE)springer-10.1007/BF02245314 Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick [Elektronische Daten] [Paul Colombo, Joe Martinez Jr, Edward Bennett, Mark Rosenzweig] To examine the role of kappa opioid receptors in memory formation, 2-day-old chicks were injected intracerebrally with either the endogenous opioid peptide dynorphin(1-13), the highly kappa selective agonist U-50,488 or the kappa selective antagonist nor-binaltorphimine (nor-BNI), given one-trial peck-avoidance training, and tested 24 h later. Dynorphin(1-13) impaired memory in a dose dependent manner at 24 h test. Injection of U-50,488 caused a biphasic dose-dependent effect on memory; low doses caused a trend toward enhanced memory and high doses caused significant impairment. Conversely, injection of low doses of nor-BNI caused a trend toward memory impairment, and higher doses caused significant memory enhancement. The results indicate that memory formation for one-trial peck-avoidance training may be modulated by kappa opioid receptor activity. Springer-Verlag, 1992 Kappa opioid receptor nationallicence Dynorphin nationallicence U-50,488 nationallicence nor-Binaltorphimine nationallicence Memory nationallicence Chick nationallicence Peck-avoidance nationallicence Opioid peptides nationallicence Colombo Paul Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Martinez Jr Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Bennett Edward Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Rosenzweig Mark Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 235-240 0033-3158 108:1-2<235 1992 108 213 https://doi.org/10.1007/BF02245314 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245314 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Colombo Paul Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Martinez Jr Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Bennett Edward Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Rosenzweig Mark Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 235-240 0033-3158 108:1-2<235 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer