caa a22 4500 469119926 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245301 doi (NATIONALLICENCE)springer-10.1007/BF02245301 Serotonergic function and late luteal phase dysphoric disorder [Elektronische Daten] [Arend Veeninga, Herman Westenberg] Thirty-eight subjects who met criteria for the DSM-III-R diagnosis late luteal phase dysphoric disorder (LLPDD) were compared with 18 controls in 5-HT uptake kinetics of the platelets in the premenstrual (day 26) as well as in the postmenstrual phase (day 4) of the cycle. Furthermore, 5-hydroxytryptophan (5-HTP) was administered to LLPDD patients and controls in both phases of the cycle, to investigate pituitary sensitivity for serotonin. Plasma samples for the measurement of cortisol and β-endorphin were taken before and after oral administration of 200 mg 5-HTP, and considered as an index of pituitary-adrenal function. LLPDD was not associated with a lower platelet 5-HT uptake and content in the premenstrual phase of the cycle, compared with the postmenstrual phase. Patients appeared not to be different from controls in 5-HT uptake kinetics of platelets in the premenstrual phase of the cycle. No main differences were observed between LLPDD patients and controls in their ability to respond with secretion of cortisol and β-endorphin to 5-HTP stimulation, either in the premenstrual, or in the postmenstrual phase. This observation could not be attributed to differences in 5-HTP metabolism. The findings of the present study do not support a specific role for 5-HT in the pathophysiology LLPDD. Springer-Verlag, 1992 Premenstrual symptoms nationallicence Late luteal phase dysphoric disorder nationallicence Serotonin nationallicence Cortisol nationallicence β-endorphin nationallicence Veeninga Arend Psychiatric Hospital "De Grote Rivieren”, P.O. Box 1001, NL-3300 BA, Dordrecht, The Netherlands aut Westenberg Herman Department of Biological Psychiatry, Academic Hospital, P.O. Box 85500, NL-3508 GA, Utrecht, The Netherlands aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 153-158 0033-3158 108:1-2<153 1992 108 213 https://doi.org/10.1007/BF02245301 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245301 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Veeninga Arend Psychiatric Hospital "De Grote Rivieren”, P.O. Box 1001, NL-3300 BA, Dordrecht, The Netherlands aut NATIONALLICENCE 700 1- Westenberg Herman Department of Biological Psychiatry, Academic Hospital, P.O. Box 85500, NL-3508 GA, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 153-158 0033-3158 108:1-2<153 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer