caa a22 4500 469119934 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245308 doi (NATIONALLICENCE)springer-10.1007/BF02245308 Beta-CCE and FG 7142 increase defensiveness during intraspecies encounters in mice [Elektronische Daten] [A. Šulcová, M. Kršiak, P. Donát] The effects were ascertained of two partial inverse agonists at benzodiazepine receptors (beta-CCE and FG 7142) on the incidence of timid (defensive-escape), aggressive, sociable and locomotor activities in both timid and aggressive singly-housed male mice, treated with drugs in paired interactions with untreated non-aggressive males. FG 7142 (5 mg/kg) and beta-CCE (8 mg/kg) increased defenses and escapes without producing other behavioral changes in timid mice. FG 7142 (20 mg/kg) and beta-CCE (1-8 mg/kg) moderately increased defenses and alert postures in aggressive mice and this effect was associated with marked reduction of aggressive behavior. FG 7142 (20 and 80 mg/kg) also decreased walking across cage in aggressive mice. It is concluded that beta-CCE and FG 7142 produced behavioral changes which could be interpreted as "anxiogenic”. Springer-Verlag, 1992 Beta-CCE nationallicence FG 7142 nationallicence Anxiogenic property nationallicence Defensive behavior nationallicence Animal models of anxiety nationallicence Šulcová A. Department of Pharmacology, Faculty of Medicine, Masaryk University, Joštova 10, CS-662 43, Brno, Czechoslovakia aut Kršiak M. Institute of Pharmacology, Czechoslovak Academy of Sciences, Albertov 4, CS-128 00, Praha 2, Czechoslovakia aut Donát P. Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Legerova 63, CS-120 00, Praha 2, Czechoslovakia aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 205-209 0033-3158 108:1-2<205 1992 108 213 https://doi.org/10.1007/BF02245308 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245308 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Šulcová A. Department of Pharmacology, Faculty of Medicine, Masaryk University, Joštova 10, CS-662 43, Brno, Czechoslovakia aut NATIONALLICENCE 700 1- Kršiak M. Institute of Pharmacology, Czechoslovak Academy of Sciences, Albertov 4, CS-128 00, Praha 2, Czechoslovakia aut NATIONALLICENCE 700 1- Donát P. Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Legerova 63, CS-120 00, Praha 2, Czechoslovakia aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 205-209 0033-3158 108:1-2<205 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer