caa a22 4500 469119977 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245280 doi (NATIONALLICENCE)springer-10.1007/BF02245280 Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats [Elektronische Daten] [Kathleen Melia, Eric Nestler, Ronald Duman] Previous studies have demonstrated that chronic stress increases and antidepressant treatments decrease levels of tyrosine hydroxylase (TH) in locus coeruleus (LC). In the present study, the influence of chronic antidepressant treatment on the induction of TH immunoreactivity in response to cold stress is examined. It was found that chronic imipramine pretreatment (18 days) attenuated the induction of TH in response to cold stress, resulting in levels of TH immunoreactivity not different from control. In contrast, imipramine pretreatment for 1 or 7 days was not sufficient to normalize the stress-induced elevation of TH immunoreactivity. These findings raise the possibility that the therapeutic action of antidepressants may be derived, in part, from the ability of these treatments to normalize levels of TH and thereby the function of the NE neurotransmitter system under conditions of stress. Springer-Verlag, 1992 Tyrosine hydroxylase nationallicence Locus coeruleus nationallicence Stress nationallicence Antidepressants nationallicence Imipramine nationallicence LC : locus coeruleus nationallicence NE : norepinephrine nationallicence TH : tyrosine hydroxylase nationallicence Melia Kathleen Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut Nestler Eric Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut Duman Ronald Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 23-26 0033-3158 108:1-2<23 1992 108 213 https://doi.org/10.1007/BF02245280 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245280 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Melia Kathleen Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut NATIONALLICENCE 700 1- Nestler Eric Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut NATIONALLICENCE 700 1- Duman Ronald Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center, 34 Park Street, 06508, New Haven, CT, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 23-26 0033-3158 108:1-2<23 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer