caa a22 4500 469119985 CHVBK 20180323133135.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245307 doi (NATIONALLICENCE)springer-10.1007/BF02245307 Increased GABAA-dependent chloride uptake in mice selectively bred for low aggressive behavior [Elektronische Daten] [Elise Weerts, Lawrence Miller, Kathryn Hood, Klaus Miczek] Selective breeding for aggressive behavior alters GABA-dependent chloride uptake and behavioral response to benzodiazepine treatment. Pharmacological and biochemical studies examined subjects from three lines of adult male ICR mice selectively bred for either high levels or low levels of aggressive behavior, as well as unselected controls. Selective breeding produced two lines of behaviorally distinct males. During 5-min dyadic confrontations with an outbred stimulus animal, untreated low-aggressive mice spent more time in walking, rearing, and social interaction than untreated high-aggressive mice. The three lines also showed different responsiveness to the aggression increasing and decreasing effects as well as the sedative effects of benzodiazepine treatment. High doses of chlordiazepoxide (17, 30 mg/kg) reduced motor behaviors (walk, rear and groom) in the low-aggressive line without altering these behaviors in the high aggressive line. In the high-aggressive line, the same doses of chlordiazepoxide (17, 30 mg/kg) produced a behavioral shift; aggressive behaviors were reduced while social behaviors increased to levels similar to the untreated low-aggressive line. In contrast, only the unselected line pursued and threatened more after a low dose of chlordiazepoxide (3 mg/kg). The three lines also showed alterations at the GABAA-benzodiazepine receptor complex. Specific uptake of [3H]Ro-15-1788 was increased in cerebral cortex, hypothalamus and hippocampus in the low-aggressive line, and was reduced in these areas in high-aggressive line when compared with unselected controls. Similarly, GABA-dependent chloride uptake in cortical synaptoneurosomes was augmented in low-aggressive mice and decreased in high-aggressive mice when compared to unselected controls. These data suggest a direct relationship between GABAA-benzodiazepine receptor function and the predisposition to initiate aggressive behavior. Springer-Verlag, 1992 Benzodiazepines nationallicence GABA nationallicence Aggression nationallicence Motor activity nationallicence Locomotion nationallicence Agonistic behavior nationallicence Animal behavior nationallicence Weerts Elise Department of Psychology, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut Miller Lawrence Department of Pharmacology, Tufts University, 02111, Boston, MA, USA aut Hood Kathryn College of Health and Human Development, Pennsylvania State University, 16802, University Park, PA, USA aut Miczek Klaus Department of Psychology, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 196-204 0033-3158 108:1-2<196 1992 108 213 https://doi.org/10.1007/BF02245307 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245307 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weerts Elise Department of Psychology, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut NATIONALLICENCE 700 1- Miller Lawrence Department of Pharmacology, Tufts University, 02111, Boston, MA, USA aut NATIONALLICENCE 700 1- Hood Kathryn College of Health and Human Development, Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Miczek Klaus Department of Psychology, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 196-204 0033-3158 108:1-2<196 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer