caa a22 4500 469120029 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245295 doi (NATIONALLICENCE)springer-10.1007/BF02245295 Interaction of sigma and PCP-like drugs on operant behaviors in the rat [Elektronische Daten] [Thomas Hudzik, Barbara Slifer] Many PCP-like drugs interact with at least two types of binding sites in the CNS, one of which is linked to excitatory amino acid transmission and the other with an unknown function. The present experiments were designed to further clarify the mechanism of action of drugs in this class. Assessment was made of the effects of PCP, MK-801, (+)-pentazocine, (+)- and (−)-N-allylnormetazocine (NANM), (+)-amphetamine and BMY-14802 in rats responding under a multiple timeout 600 s (TO), differential reinforcement of low rates 10 s (DRL), fixed ratio (FR) 10 schedule of reinforcement. The effects of the PCP-receptor selective drug MK-801 were compared to those of the mixed sigma/PCP drug (+)-NANM after each were combined with doses of (+)-pentazocine, PCP, BMY-14802, and (+)-amphetamine. MK-801 was also tested in combination with (+)-NANM, as was PCP with BMY-14802. When administered alone, MK-801, PCP, (+)-NANM, (+)-pentazocine, and (+)-amphetamine increased rates of responding under the DRL component of the multiple schedule. The drugs tested generally produced decreases in rates of responding under the FR component. (+)-Pentazocine and BMY-14802 did not modify the effects of (+)-NANM or of MK-801. PCP enhanced the effects of MK-801 and (+)-NANM, and (+)-amphetamine enhanced the effects of MK-801 but not of (+)-NANM. BMY-14802 attenuated the effects of PCP. Taken together, these data suggest similarities as well as some differences in the pharmacologic activities of MK-801 and (+)-NANM and PCP. Springer-Verlag, 1992 Phencyclidine nationallicence MK-801 nationallicence N-allylnormetazocine nationallicence Schedule-controlled behavior nationallicence Drug interactions nationallicence DRL nationallicence FR nationallicence Hudzik Thomas Behavioral Pharmacology Laboratory, Department of Psychology, University of New Orleans, 70148, New Orleans, LA, USA aut Slifer Barbara Behavioral Pharmacology Laboratory, Department of Psychology, University of New Orleans, 70148, New Orleans, LA, USA aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 115-122 0033-3158 108:1-2<115 1992 108 213 https://doi.org/10.1007/BF02245295 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245295 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hudzik Thomas Behavioral Pharmacology Laboratory, Department of Psychology, University of New Orleans, 70148, New Orleans, LA, USA aut NATIONALLICENCE 700 1- Slifer Barbara Behavioral Pharmacology Laboratory, Department of Psychology, University of New Orleans, 70148, New Orleans, LA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 115-122 0033-3158 108:1-2<115 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer