caa a22 4500 469120037 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02245309 doi (NATIONALLICENCE)springer-10.1007/BF02245309 Age-related changes in serotonin 5HT2 receptors on human blood platelets [Elektronische Daten] [Anat Biegon, Nachman Greuner] Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserine. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in receptor binding. Among the ages sampled, the highest levels of 5HT2 receptor binding were found in 6-year-olds. A sharp decline in receptor binding occured during adolescence, with levels reduced by half between ages 13 and 17. This pattern is similar to the one we have observed in brain 5HT2 receptors postmortem. There were no significant sex differences in 5HT2 receptors on platelets in newborn and young children. A trend towards higher binding in girls appears around the onset of menstruation in teenage girls (age 14 and up). These results demonstrate that platelet 5HT2 receptors can serve as a model for age dependent changes in 5HT2 receptors in the brain. Springer-Verlag, 1992 Serotonin receptors nationallicence Ketanserine nationallicence Platelet nationallicence Biegon Anat Lawrence Berkeley Laboratory, University of California, 1 Cyclotron Road, 94720, Berkeley, CA, USA aut Greuner Nachman Department of Biochemistry and the Biochemical Research Unit, Carmel Hospital, Haifa, Israel aut Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 210-212 0033-3158 108:1-2<210 1992 108 213 https://doi.org/10.1007/BF02245309 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245309 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biegon Anat Lawrence Berkeley Laboratory, University of California, 1 Cyclotron Road, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Greuner Nachman Department of Biochemistry and the Biochemical Research Unit, Carmel Hospital, Haifa, Israel aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 108/1-2(1992-07-01), 210-212 0033-3158 108:1-2<210 1992 108 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer