caa a22 4500 469120088 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244962 doi (NATIONALLICENCE)springer-10.1007/BF02244962 Chronic treatment with meta-chlorophenylpiperazine (m-CPP) alters behavioral and cerebral metabolic responses to the serotonin agonists m-CPP and quipazine but not 8-hydroxy-2(di-N-propylamino)tetralin [Elektronische Daten] [Ulderico Freo, Harold Holloway, Nigel Greig, Timothy Soncrant] The effects of the serotonin (5-HT) agonists meta-chlorophenylpiperazine (m-CPP), quipazine and 8-hydroxy-2(di-n-propylamino)tetralin (DPAT) on behavior and on regional cerebral metabolic rates for glucose (rCMRglc) were measured in control rats or in rats pretreated for 2 weeks with continuous infusion of saline or m-CPP (2.5 mg/kg/day, subcutaneously). rCMRglc was measured in 71 brain regions, using the quantitative autoradiographic [14C]2-deoxy-D-glucose technique, at 15 min after acute administration of m-CPP 2.5 mg/kg, 60 min after quipazine 20 mg/kg, or 10 min after DPAT 1 mg/kg. Behavioral effects were assessed for m-CPP with an activity monitor, for quipazine by counting head shakes and for DPAT by scoring the serotonin syndrome. Chronic m-CPP pretreatment produced tolerance to hypolocomotion induced by acute m-CPP and to head shakes caused by acute quipazine, but did not alter the serotonin syndrome produced by DPAT. m-CPP 2.5 mg/kg IP produced widespread rCMRglc reductions in control rats but failed to modify rCMRglc in any region after chronic m-CPP pretreatment. Quipazine increased rCMRglc in 4 regions in control rats, but reduced rCMRglc in 14 brain areas of chronically m-CPP-pretreated animals. DPAT altered rCMRglc to the same degree in control (25 regions affected) and in chronically m-CPP-pretreated rats (28 regions affected). Reduced behavioral and metabolic effects of acute m-CPP in chronically m-CPP-pretreated rats were not due to pharmacokinetic alterations. These results demonstrate that chronic administration of m-CPP produces behavioral and metabolic tolerance to acute administration of m-CPP, but not of DPAT. They suggest that hypolocomotion and the serotonin syndrome are mediated by different 5-HT receptor subtypes, and that chronic m-CPP administration produces functional down-regulation of 5-HT1B/1C but not of 5-HT1A-coupled mechanisms. Springer-Verlag, 1992 Deoxyglucose nationallicence Serotonin nationallicence Meta-chlorophenylpiperazine nationallicence Quipazine nationallicence 8-Hydroxy-2(di-N-propylamino)tetralin nationallicence Freo Ulderico Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut Holloway Harold Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut Greig Nigel Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut Soncrant Timothy Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 30-38 0033-3158 107:1<30 1992 107 213 https://doi.org/10.1007/BF02244962 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244962 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Freo Ulderico Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Holloway Harold Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Greig Nigel Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Soncrant Timothy Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 30-38 0033-3158 107:1<30 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer