caa a22 4500 469120118 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244964 doi (NATIONALLICENCE)springer-10.1007/BF02244964 Effects of calcitonin on human auditory and visual evoked brain potentials [Elektronische Daten] [Reinhard Pietrowsky, Marcus Dentler, Horst Fehm, Jan Born] Besides its Ca++-regulative effects, calcitonin is known to diminish sensitivity to painful stimuli. The present study aimed to clarify whether calcitonin has similar effects on stimulus processing in other modalities. Effects of calcitonin were assessed on brain potentials recorded from the human scalp which were evoked either by auditory clicks or visual checkerboard pattern-reversals. Twelve healthy men were tested in a double-blind intra-subject design receiving either 0.1 IU/kg salmon calcitonin (sCT) or 1.0 IU/kg sCT or saline solution during a 20 min IV infusion. sCT significantly increased latency of wave V of the brainstem auditory evoked potential (BAEP). Effects on BAEP wave V increased in magnitude with increasing dose of sCT and with decreasing intensity of the click stimulus. There was also a slight increase in latency of the N80 of the pattern-reversal visual evoked potential (PR-VEP). Additionally, subjects rated themselves as less activated following the high dose of sCT compared to placebo. The pattern of results is in accord with a slowing or inhibitory influence of calcitonin on auditory and visual sensory processing, thus paralleling findings concerning calcitonin effects on the perception of painful somatosensory stimuli. Springer-Verlag, 1992 Calcitonin nationallicence CGRP nationallicence Evoked brain potentials nationallicence Sensory processing nationallicence Cortisol nationallicence ACTH nationallicence Activation nationallicence Pietrowsky Reinhard Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut Dentler Marcus Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut Fehm Horst Internal Medicine, University of Lübeck, W-2400, Lübeck, Federal Republic of Germany aut Born Jan Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 50-54 0033-3158 107:1<50 1992 107 213 https://doi.org/10.1007/BF02244964 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244964 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pietrowsky Reinhard Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Dentler Marcus Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Fehm Horst Internal Medicine, University of Lübeck, W-2400, Lübeck, Federal Republic of Germany aut NATIONALLICENCE 700 1- Born Jan Department of Psychophysiology, University of Bamberg, P.O. Box 1549, W-8600, Bamberg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 50-54 0033-3158 107:1<50 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer