caa a22 4500 469120134 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244966 doi (NATIONALLICENCE)springer-10.1007/BF02244966 Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action [Elektronische Daten] [A. Fernández-Guasti, E. Hong, C. López-Rubalcava] The effect of three anxiolytic drugs, indorenate, ipsapirone and diazepam, on the burying behaviour of rats and mice was studied. All three drugs induced a reduction in burying behaviour interpreted as a reduction in anxiety. However, a species difference in the diazepam sensitivity was found: rats showed a clear effect after 1.0 mg/kg while already at 0.25 mg/kg an action was observed in mice. The serotonergic anxiolytics produced similar responses at similar doses (2.5-5.0 mg/kg) in both species. The serotonergic antagonists, pindolol (3.1 mg/kg), alprenolol (5.0 mg/kg) and methiotepin (0.31 mg/kg), induced a slight reduction in the time spent burying but effectively counteracted the anxiolytic action of the serotonergic agonists in mice but not in rats. By contrast, in rats, the beta blocker, practolol (0.5 mg/kg), was the only drug effective in preventing the anxiolytic actions of ipsapirone. The combined treatment of indorenate and methiotepin resulted in an impairment of motor coordination and ambulatory behaviour in both species studied, thereby suggesting that the lack of effect of such combination was mediated by altering the motor behaviour. Finally, the reduction in ambulatory behaviour in mice produced by ipsapirone was effectively prevented by the antagonists methiotepin, pindolol and alprenolol indicating the involvement of a serotonergic receptor in this effect. From these results it is concluded that a different mechanism underlies the anxiolytic actions of indorenate and ipsapirone in mice and rats. Springer-Verlag, 1992 Indorenate nationallicence Ipsapirone nationallicence Diazepam nationallicence Beta-blockers nationallicence 5-HT1 antagonists nationallicence Burying behaviour nationallicence Fernández-Guasti A. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut Hong E. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut López-Rubalcava C. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 61-68 0033-3158 107:1<61 1992 107 213 https://doi.org/10.1007/BF02244966 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244966 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-Guasti A. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut NATIONALLICENCE 700 1- Hong E. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut NATIONALLICENCE 700 1- López-Rubalcava C. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México D.F., México aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 61-68 0033-3158 107:1<61 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer