caa a22 4500 469120150 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244976 doi (NATIONALLICENCE)springer-10.1007/BF02244976 Locomotor responses to benzodiazepines, barbiturates and ethanol in diazepam-sensitive (DS) and -resistant (DR) mice [Elektronische Daten] [Tamara Phillips, Edward Gallaher] Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensitivity to the locomtor stimulant effects of several doses of diazepam, flunitrazepam, pentobarbital, phenobarbital, and ethanol. DR mice were more sensitive than DS mice to the locomotor stimulant effects of all drugs except phenobarbital. These results largely support the hypothesis that a common biological mechanism mediates sensitivity to the stimulant effects of sedative-hypnotic drugs. Receptor mediation of the benzodiazepine effects was examined by administering the benzodiazepine receptor antagonist, RO15-1788. Locomotor depression produced by diazepam and flunitrazepam in DS mice was blocked by RO15-1788. However, while the locomotor stimulation produced by diazepam in DR mice was antagonized, the stimulant effect of flunitrazepam was not. This suggests that binding of flunitrazepam to the GABAA-benzodiazepine receptor is not necessary for production of locomotor stimulation. Springer-Verlag, 1992 DS mice nationallicence DR mice nationallicence Selective breeding nationallicence Locomotor stimulation nationallicence Benzodiazepines nationallicence Alcohol nationallicence Ethanol nationallicence Barbiturates nationallicence Phillips Tamara Research Service, VA Medical Center, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, OR, USA aut Gallaher Edward Research Service, VA Medical Center, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, OR, USA aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 125-131 0033-3158 107:1<125 1992 107 213 https://doi.org/10.1007/BF02244976 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244976 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Phillips Tamara Research Service, VA Medical Center, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, OR, USA aut NATIONALLICENCE 700 1- Gallaher Edward Research Service, VA Medical Center, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, OR, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 125-131 0033-3158 107:1<125 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer