caa a22 4500 469120177 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244969 doi (NATIONALLICENCE)springer-10.1007/BF02244969 Tolerance to the effects of ethanol on the speed and success of reaction time responding in the rat: effects of age and intoxicated practice [Elektronische Daten] [R. Dayne Mayfield, Mitzie Grant, Timothy Schallert, Waneen Spirduso] An animal model of human reaction time (RT) was used to investigate the effects of age and intoxicated practice on the development of tolerance to the motor impairing effects of ethanol (EtOH). Young (8-9 month) and old (24-26 month) Fischer 344 rats were trained to release a lever in response to an auditory and visual stimulus in order to avoid mild footshock. The animals were divided into groups to receive either intoxicated (EtOH-before) or unintoxicated (EtOH-after) RT testing. Successful avoidance and response latencies were impaired in young and old rats after the initial exposure to EtOH (EtOH-before group). Tolerance developed to EtOH's effects on successful avoidance and on response latencies whether or not the rats received intoxicated RT practice; however, intoxicated practice facilitated tolerance development to EtOH's effects on successful avoidance but not on response latencies. While the initial sensitivity and the level of tolerance that developed to EtOH's effects were similar in young and old rats, the old rats were generally more sensitive to EtOH and developed tolerance at a slower rate. These results suggest that tolerance develops to the effects of EtOH on RT and that intoxicated practice can have different effects on the parameters of the behavioral response. Springer-Verlag, 1992 Ethanol nationallicence Tolerance nationallicence Aging nationallicence Behavior nationallicence Reaction time nationallicence Dayne Mayfield R. Department of Kinesiology, The University of Texas at Austin, 78712, Austin, TX, USA aut Grant Mitzie Department of Psychology, The University of Texas at Austin, 78712, Austin, TX, USA aut Schallert Timothy Department of Psychology, The University of Texas at Austin, 78712, Austin, TX, USA aut Spirduso Waneen Department of Kinesiology, The University of Texas at Austin, 78712, Austin, TX, USA aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 78-82 0033-3158 107:1<78 1992 107 213 https://doi.org/10.1007/BF02244969 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244969 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dayne Mayfield R. Department of Kinesiology, The University of Texas at Austin, 78712, Austin, TX, USA aut NATIONALLICENCE 700 1- Grant Mitzie Department of Psychology, The University of Texas at Austin, 78712, Austin, TX, USA aut NATIONALLICENCE 700 1- Schallert Timothy Department of Psychology, The University of Texas at Austin, 78712, Austin, TX, USA aut NATIONALLICENCE 700 1- Spirduso Waneen Department of Kinesiology, The University of Texas at Austin, 78712, Austin, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 78-82 0033-3158 107:1<78 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer