caa a22 4500 469120185 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244967 doi (NATIONALLICENCE)springer-10.1007/BF02244967 Quantification of naturally occurring benzodiazepine-like substances in human breast milk [Elektronische Daten] [Sven Dencker, Gunvor Johansson, Ian Milsom] The possible occurrence of benzodiazepine-like substances in human breast milk was investigated in 35 healthy, newly delivered women who were known not to be taking benzodiazepines. Maternal blood samples and a sample of breast milk were obtained on the fifth post partum day. A radioreceptor technique (lower limit of detection 1.5 ng/ml; difference between duplicates at various concentrations <7%) was used for measuring benzodiazepine-like substances in blood and breast milk (with and without prior extraction). No benzodiazepine-like substances could be demonstrated in any of the blood samples taken from the 35 women. Measurable concentrations of benzodiazepine-like substances were demonstrated in all but 1 of the 35 breast milk samples. The mean concentration of benzodiazepine-like substances for all 35 women was 4.3±2.3 ng/ml (range 0-9.3 ng/ml) expressed as lorazepam. The corresponding value for extracted breast milk was 2.6±1.5 ng/ml (range 0-7.0 ng/ml). There was no association between concentrations of benzodiazepine-like substances in breast milk and maternal age, weight, height and body mass or parity, or the sex of the infant and infant birth weight. We suggest that non-detectable amounts of benzodiazepine-like substances in serum are concentrated in the mammillary glands and excreted in a higher concentration in breast milk. It is less likely that the relevant benzodiazepines are produced in the mammillary glands. Springer-Verlag, 1992 Benzodiazepines nationallicence Human breast milk nationallicence Endogenous nationallicence Radioreceptor assay nationallicence Mammillary gland nationallicence Dencker Sven Department II of Psychiatry, Lillhagen Hospital, Box 3005, S-42203, Hisings Backa, Sweden aut Johansson Gunvor Department II of Psychiatry, Lillhagen Hospital, Box 3005, S-42203, Hisings Backa, Sweden aut Milsom Ian Department of Obstetrics and Gynecology, East Hospital, S-41685, Göteborg, Sweden aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 69-72 0033-3158 107:1<69 1992 107 213 https://doi.org/10.1007/BF02244967 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244967 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dencker Sven Department II of Psychiatry, Lillhagen Hospital, Box 3005, S-42203, Hisings Backa, Sweden aut NATIONALLICENCE 700 1- Johansson Gunvor Department II of Psychiatry, Lillhagen Hospital, Box 3005, S-42203, Hisings Backa, Sweden aut NATIONALLICENCE 700 1- Milsom Ian Department of Obstetrics and Gynecology, East Hospital, S-41685, Göteborg, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 69-72 0033-3158 107:1<69 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer